To activate Netspend card over the phone you can call Netspend call center that is 1-866-387-7363. You will share your card number and SSN number. The above mentioned phone number for Netspend card activation is not available 24*7. Phone service is available from Monday to Friday between 8 AM to 6 PM and on Saturday and Sunday between 8 AM to 5 PM. Though you always can call us even in odd hours and activate your card as we work round the clock.